Ferric Ions Are Essential for the Biological Activity of the Hormone
نویسندگان
چکیده
From the ‡University of Melbourne Department of Surgery, Austin Campus, ARMC, Heidelberg, Victoria 3084, Australia, the §Department of Pathology, The University of Melbourne, and The Mental Health Research Institute of Victoria, Parkville, Victoria 3010, Australia, ¶Laboratoire de Signalisation Cellulaire et Tumorale, EA MNRT 2995, Faculté de Pharmacie, Montpellier, France, and the Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
منابع مشابه
Ferric ions are essential for the biological activity of the hormone glycine-extended gastrin.
Amidated and nonamidated gastrins elicit different biological effects via distinct receptors in different tissues. Amidated gastrin 17 stimulates gastric acid secretion and the development of gastric carcinoids, whereas glycine-extended gastrin 17 stimulates proliferation of the colonic mucosa and the development of colorectal cancers. Because glycine-extended gastrin 17 binds two ferric ions w...
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